Thông tin khoa học

The indicated non-communicable diseases are closely related to the aging process (top). A range of cellular stresses cause stable proliferation arrest and contribute to cellular senescence. This is accompanied by a potent proinflammatory secretome, which is represented by increased amounts of chemokines, cytokines, proteases and growth factors. They influence their cellular environment and lead to systemic chronic inflammation or “inflammaging” in aged tissue, which promotes the progression of the indicated noncommunicable diseases (outer circle, bottom). This is related to the 12 hallmarks of aging, which are often monitored by approaches of epigenomics, transcriptomics, proteomics, metabolomics, glycomics and microbiomics (inner circle, bottom). BMF= bone marrow failure, CCL= chemokine C–C motif ligand, COPD = chronic obstructive pulmonary disease, IGF1 = insulin-like growth factor, IL = interleukin, MCP1 = monocyte chemoattractant protein 1, MMP = matrix metalloproteinase, NAFLD = non-alcoholic fatty liver disease, TGFβ = transforming growth factor β,TNF = tumor necrosis factor

(TS. Đinh Phong Sơn)